http://rmforall.blogspot.com/2012/01/tobacco-activist-victor-j-de-noble-and.html
http://health.groups.yahoo.com/group/aspartameNM/message/1637
http://www.addictionincorporated.com/
http://www.addictionincorporated.com/contact-us/
http://www.facebook.com/AddictionIncorporated?sk=wall
http://www.utsandiego.com/news/2012/jan/27/tp-victor-denoble/
Whistle-Blower Still Making Noise
Victor DeNoble [ photo ]
Former cigarette researcher narrates new documentary
Written by
Peter Rowe
12:01 a.m., Jan. 27, 2012
http://www.utsandiego.com/staff/peter-rowe/contact/
Facebook: Brewery Rowe
Twitter: @@peterroweut
Also of interest:
Cutting through the smoke
Philip Morris couldn't snuff out Victor DeNoble
FTC voids tobacco testing method
S.F. mayor proposes cigarette-butt tax
Two tobacco firms file suit to block marketing rules
[ What:
Victor DeNoble and director Charles Evans Jr. will answer questions about "Addiction Incorporated"
Running time: 1 hour, 42 minutes
When: After the 7 p.m. screening, Friday and Saturday
Where: Landmark Ken Cinema, 4061 Adams Ave., San Diego
[ 805 N to 15 N, 2 miles to E on Adams Avenue, 200 feet on south side ]
Information: (619) 819-0236
landmarktheatres.com ]
Philip Morris fired cigarette researcher Victor DeNoble, but that wasn’t enough.
His lab was closed, his lab rats killed, his studies buried.
Company lawyers forced him to sign a lifetime nondisclosure statement.
His work on nicotine addiction was so dangerous, Philip Morris wanted to erase every trace of DeNoble.
How’s that going, Phil?
DeNoble, 62, has become one of the nation’s most prominent anti-smoking campaigners.
The San Diego resident travels constantly, speaks to 350,000 students a year -- delivering up to four talks a day -- and tangles with the tobacco industry in legislative chambers and courtrooms.
Now the star of "Addiction Incorporated," a new documentary that opens here today, is hailed as a whistle-blower whose testimony made possible the $206 billion settlement U.S. tobacco companies approved in 1998.
He has the brains of a Bill Gates and, to hear some critics, the on-screen charisma of a Brad Pitt.
DeNoble “reveals himself to be a born raconteur,” The New York Times’ Jeannette Catsoulis wrote.
“His easygoing, self-deprecating narration is the film’s most valuable asset and the viewer’s best friend.”
Not bad for someone who was supposed to be a nonperson.
But DeNoble’s story is a curious one, full of odd turns and a bizarre quest.
The key chapter begins in 1980, when he was hired by Philip Morris -- the parent corporation of Marlboro, Virginia Slims, Benson & Hedges and many other brands -- to research “safer” cigarettes.
In 1983, he succeeded.
And sealed his fate.
Proof negative
Growing up on Long Island, N.Y., Victor struggled to read and comprehend his school lessons.
No scholar, he assumed he would follow in his father’s footsteps as a plumber.
Dad, though, insisted that Victor apply for college.
“Why?” the teenager asked.
“To meet smart women, stupid.”
At Adelphi University, Victor met women and made another, non-hormone-related, discovery.
He wasn’t dumb; he was dyslexic.
To his eyes, printed words appeared backward.
Victor relearned to read -- and his grades soared.
Studying drug addiction, he earned a bachelor’s degree and then a doctorate.
Recruited by Philip Morris, the young Ph.D. naively accepted assurances that the tobacco giant wanted good science and good works.
“In 1979,” he noted, “smoking had no stigma.
You could smoke anywhere.
They came to me and said,
‘We are killing a whole bunch of people. Can you help us save some people?’ ”
Every year, DeNoble was informed, 138,000 smokers die from nicotine-induced heart attacks and brain strokes.
What if Philip Morris could market a cigarette that caused no cardiovascular damage?
Experimenting with rats in the corporation’s labs, DeNoble found a nicotine substitute, 2 prime methyl-nicotine.
It didn’t damage the heart -- yet was equally addictive.
The news thrilled DeNoble’s bosses, until they realized that cigarettes with chemical additives would be scrutinized by the U.S. Food and Drug Administration.
“Damn it,” DeNoble was told, “you’ve made us into a pharmaceutical company.”
His research, though, was proof positive that nicotine addicted.
With his supervisors’ permission, DeNoble and two co-authors submitted their findings to a professional publication.
It was scheduled for the Journal of Psychopharmacology’s September 1983 issue when DeNoble was forced to withdraw the paper.
In the view of Philip Morris’ lawyers, the scientists’ proof positive was a legal proof negative, damning evidence that cigarettes were drugs.
Still, DeNoble won promotions and more funds for his lab.
When he and a colleague, Paul Mele, were summoned to see their boss on April 5, 1984, he expected good news.
Instead, they were fired and muzzled.
To receive a severance package, they were forced to agree to never discuss their work.
No. 1 whistle-blower
In 1994, a decade after DeNoble’s firing, he was contacted by federal investigators.
FDA Chairman David Kessler, about to appear before a congressional committee investigating tobacco’s health effects, needed experts to brief him.
Could DeNoble help?
Citing the nondisclosure agreement, DeNoble declined.
That wasn’t good enough.
In one of the most dramatic scenes of “Addiction Incorporated,” Los Angeles congressman Henry Waxman presses the CEO of Philip Morris to release DeNoble from this agreement.
After numerous evasions, the tobacco executive finally agrees.
Two weeks later, DeNoble testified that nicotine is addictive, that Philip Morris knew this, and that the corporation -- and, no doubt, its competitors-- sought ways to heighten this effect.
This is all common knowledge -- now.
Then?
“Victor DeNoble was the first whistle-blower,” Waxman said in the documentary.
“I know a lot of people have talked about other whistle-blowers.
But he was the first one.”
As "Addiction Incorporated" notes, DeNoble became a key ally of the state attorneys general who sued the tobacco companies, eventually winning that landmark $209 billion settlement.
Despite this payout, big tobacco is bigger than ever -- Philip Morris, for instance, has seen its stock price climb 51 percent in the past five years.
Will "Addiction Incorporated” further tarnish these corporations?
Philip Morris did not address questions about DeNoble and his research but a company spokesman did comment on the movie.
“This film covers topics regarding smoking that have been in the public domain for some time,” David Sutton, a Philip Morris USA spokesman, said via email Thursday.
“PM USA agrees with the overwhelming medical and scientific consensus that cigarette smoking is addictive and causes serious diseases in smokers.”
“Addiction Incorporated” concludes with President Barack Obama signing a 2009 law expanding the FDA’s oversight to include cigarettes.
“PM USA stood alone among the major cigarette manufacturers in support of FDA regulation over cigarettes,” Sutton noted, “and believes that this regulation can provide significant benefits to tobacco manufacturers and adult tobacco consumers.”
That’s not enough, DeNoble argues.
The movie shows him running on the trails near the Santa Luz home he shares with his wife, Kimi DeNoble, but those jogs are rare occasions.
More often, he’s running to airports or classrooms, preparing to talk to students about science, nicotine and rats -- both four- and two-legged varieties.
How could he ever believe that a tobacco company would want a safer cancer stick?
He smiled.
These days, his close-cropped hair is graying and his face has acquired a few wrinkles.
But there’s still something fresh and idealistic about that smile.
“I was young,” he said, “and I was wrong.”
http://www.utsandiego.com/news/2012/jan/25/philip-morris-couldnt-snuff-out-victor-denoble/
Philip Morris couldn't snuff out Victor DeNoble
New documentary lights up addiction scientist's story
[ photo of face ]
Victor DeNoble moved to San Diego seven years ago -- John R. McCutchen
[ same story ]
http://www.utsandiego.com/news/2012/jan/26/tp-cutting-through-the-smoke/
Movie review
Cutting through the smoke
"Addiction Incorporated" documents the moral and legal conflicts behind the nicotine business
By JEANNETTE CATSOULIS NYT News Service
12:01 a.m., Jan. 26, 2012
Also of interest:
Puff, puff, puff, nicotine rises gradually
The U-T's "On the Move" column
White House: Not smoking a struggle for Obama
SDSU candidate fields wide array of questions
“Addiction Incorporated ”
Rating: PG
When: Opens Friday
Where: Landmark Ken
Running time: 1 hour, 42 minutes
***
Straight-shooting, hard-hitting and fuming with contempt for the tobacco industry, “Addiction Incorporated” would be almost too exhausting to watch were it not for the folksy charm of its star witness.
Nestled at the center of this relentless documentary, guiding us through a deluge of scientific evidence and corporate bobbing and weaving, is the scientist and whistle-blower Victor J. DeNoble, who a San Diego resident, who reveals himself to be a born raconteur.
His easygoing, self-deprecating narration is the film’s most valuable asset and the viewer’s best friend.
Hired by Philip Morris in 1980 to test nicotine alternatives for a more heart-healthy cigarette, DeNoble, armed with his Ph.D. in experimental psychology, quickly discovered just how addictive the chemical could be.
When his test rats couldn’t get through their day without an ever-increasing number of nicotine hits -- topping out at an astonishing 90 puff equivalents a day -- DeNoble and his employers were equally shocked, though their reactions to the findings were very different.
Essentially the story of how cigarettes became subject to federal regulation, “Addiction Incorporated” lays out a meticulous, methodical time line of moral and legal conflict.
Wrangling an unwieldy mob of scientists, politicians, journalists and legal experts, the director, Charles Evans Jr., wisely trusts DeNoble to connect dots and provide clarity.
Cheeky animation of anthropomorphized rats -- and the dash and swagger of a team of Louisiana lawyers -- burn through the factual fog, while familiar video clips remind us of the saga’s heroes and villains.
Yet this heartening tale of good science stomping bad business would be drier than a week-old butt without DeNoble.
I wonder if he has a doppelgänger in the financial services industry?
http://www.utsandiego.com/news/2010/mar/08/puff-puff-puff-nicotine-rises-gradually/
By RANDOLPH E. SCHMID, AP Science Writer
12:43 p.m., March 8, 2010
peter.rowe@utsandiego.com
Twitter: @peterroweut
Facebook: Brewery Rowe
(619) 293-1227
http://www.utsandiego.com/staff/peter-rowe/
Bio
In July 1984, Peter Rowe was hired as a writer for the San Diego Union.
He has yet to be fired.
At the Union, he wrote feature stories and worked as an editor.
When the Union merged with the Tribune in 1992, he became a Union-Tribune columnist.
A California native, Rowe attended high school in Encinitas (San Dieguito) and college in La Jolla (UCSD).
He is a graduate of UC Berkeley and Northwestern University.
He is a past president of the National Society of Newspaper Columnists, a former Fulbright scholar (Japan, 2003) and has won a handful of journalism awards. He'd trade them all for a chance to avenge his "Jeopardy!" loss (1994).
He has three sons.
Not one of them reads his stories.
He is married to a terrific woman who often rescues him from errors, in writing and in life.
These days, Rowe writes profiles and features.
He's even paid to review beers, which hardly seems fair.
He does not look like his photograph.
http://www.addictionincorporated.com/pdf/AI-presskit.pdf
VICTOR DeNOBLE STATEMENT
Scientists do research with the hope that we will have a positive impact on people’s lives.
I thought I would have that opportunity when I went to work at the Philip Morris Research Center.
I never dreamed that our research would be suppressed for over ten years and that it would take a major federal investigation, congressional hearings, and acts of Congress before my hope would be fulfilled.
Seventeen years ago, when Charlie approached me about doing a documentary, I didn’t think there was even a story.
I did not see the historical value of these events as they were unfolding, Charlie did!
I underestimated Charlie’s commitment and his passion for the project.
Working on this documentary helped me to realize how many hundreds, if not thousands, of people came together with a mission to create this public health policy change.
This documentary weaves together a multitude of events; the result of which will be felt for decades to come.
My parents nurtured in me a desire to help people.
It’s the reason I became a scientist and the reason I teach kids science.
I have dyslexia and ADHD.
When I was a kid, there was no understanding of what they were.
School, learning and just paying attention were always a struggle.
I was told I was stupid and that I may not graduate high school, much less go to college.
I believed it and I was wrong.
What motivates me today, is reaching out to kids who feel they can’t go beyond high school and show them that they have more opportunities open to them than they think.
This documentary isn’t the end of a story;
it’s just the first chapter of the events that led to the changes we’ve seen to the health policy within the United States.
The next chapters have begun to unfold with continued changes, not only in our Nation, but also with changes in public health policy in other nations around the world.
CHARLES EVANS, JR. BIO
At age nine, Charles Evans Jr.’s first film work was clearing 16mm trim bins (reconstituting picture and sound scraps) for his mother, documentarian Frances Evans, while she edited.
Evans earned his undergraduate degree at UC-Berkley with a major in “Short Story Writing.”
His thesis, a collection of short stories, won the University's Eisner Prize For Literature.
Evans went on to complete the production program at University of Southern California’s film school.
He wrote, produced and directed his thesis, “Second Son”.
Shot in 35mm, the film went on to win twelve awards including the Grand Prix at Clermont-Ferrand's competition.
Evans worked for two years at Touchstone Pictures as Director of Development for Randall Kleiser Productions, before founding Acappella Pictures in March, 1993.
Evans produced Johnny Depp's directorial debut, THE BRAVE, based on the novel by Gregory Mcdonald. Johnny and Marlon Brando starred.
he production was an official selection for competition in the 1997 Cannes film festival.
Evans' enduring commitment to produce a film on the life of Howard Hughes resulted in THE AVIATOR (2004, BAFTA, Golden Globes).
In his directorial debut, ADDICTION INCORPORATED, he tells the true story of how Victor DeNoble's unexpected discovery of an addiction ingredient in tobacco leads to both more addictive Marlboro cigarettes and Congressional testimony.
The public revelation of long held tobacco industry secrets leads journalists, politicians, attorneys and whistle blowers into an unexpected alliance, that achieves the first ever federal regulation of the tobacco industry.
“THE CAST”
VICTOR J. DeNOBLE
Dr. DeNoble received his Doctorate degree in 1976 in the field of Experimental Psychology from Adelphi University.
He held postdoctoral fellowships from both the National Institute of Alcohol and Alcohol Abuse at Downstate Medical Center in Brooklyn, New York and the National Institute of Drug Abuse at the University of Minnesota.
In 1980, while still a postdoctoral fellow, DeNoble was recruited by Philip Morris Inc. to establish a Behavioral Pharmacology Laboratory to support a nicotine analogue program to study the behavioral and physiological effects of nicotine.
Following his abrupt dismissal from Philip Morris in 1984, DeNoble worked in drug discovery for the DuPont Merck Pharmaceutical Company and Ayerst Research Laboratories, specializing in the area of Central Nervous System Diseases.
In 1994, after a congressional release from his confidentiality agreement with Philip Morris, DeNoble became the first “whistle-blower” to begin tearing down the wall of secrecy built by the tobacco industry.
He was a key witness in the federal government’s case against the industry and has testified before Congress, the Food and Drug Administration and former Vice President Al Gore’s Tobacco Settlement Committee.
Currently, DeNoble is the Vice President of Hissho, Inc., a scientific and medical communications company.
PAUL C. MELE [ helped Noble do nicotine addiction research ]
Paul Mele, Ph.D., received a B.S. in biology and psychology from Union College, and a Doctorate in Experimental Psychology from Adelphi University.
He held research positions at the University of Wisconsin, the Philip Morris Inc., and the Armed Forces Radiobiology Research Institute.
In 1995, Dr. Mele moved into technology transfer as Chief, Office of Research and Technology Applications, Walter Reed Army Institute of Research (WRAIR), where he guided WRAIR's technology transfer program on the development and commercialization of drugs, vaccines and medical devices in support of the Army's mission.
In 2000, he became the first Director of Technology Transfer for the Army's Medical Research and Materiel Command at Fort Detrick.
In this capacity, Dr. Mele oversees the Army Medical Command's patent licensing program and coordinates technology transfer activities among its component laboratories, hospitals and health care centers.
Dr. Mele is a member of the Association of University Technology Managers, the Federal Laboratory consortium, and the Association of Government Toxicologists.
He has published and presented the results of a variety of scientific investigations, and he is the recipient of the 2005 Department of Defense Technology Transfer Award.
[ photos and bios of 18 other major people in the movie ]
Low doses of ethanol prevent harm from methanol from smoking and aspartame, which otherwise the human body always quickly turns into formaldehyde via the ADH enzyme inside the cells of blood vessels and many tissues.
This is inevitably a co-factor in many diseases of civilization since 1800, ranging from heart disease to Alzheimers to cancers to birth defects like spina befida and autism, which all have been increasing rapidly since the approval of aspartame in 1981.
Prof. Woodrow C. Monte (Nutrition, Arizona State University, retired) sent Chapter 12, Autism and Other Birth Defects, to EFSA in early November 2011, with a hundred mainstream scientific references, available free as online full texts, in his comprehensive review "While Science Sleeps: A Sweetener Kills", with 740 references, published January 1 2012, with long excerpts on website WhileScienceSleeps.
His book is now available this week as an Kindle electronic book, $ 9.80 download, readable on any computer via free software, Amazon.com.
While Science Sleeps, methanol from cigarettes and aspartame becomes formaldehyde inside human cells -- Table of Contents, WC Monte bio, Kindle electronic book version $ 9.80 Amazon.com: Rich Murray 2012.01.26
http://rmforall.blogspot.com/2012/01/while-science-sleeps-methanol-from.html
http://health.groups.yahoo.com/group/aspartameNM/message/1636
new book, concise opus "While Science Sleeps" life saving facts re aspartame (methanol, formaldehyde) -- 740 full text references are free online -- Woodrow "Woody" C. Monte, retired Prof. of Nutrition, Arizona State University: Rich Murray 2012.01.03
http://rmforall.blogspot.com/2012/01/new-book-concise-opus-while-science.html
http://health.groups.yahoo.com/group/aspartameNM/message/1631
http://www.amazon.com/While-Science-Sleeps-Woodrow-Monte/dp/1452893675/ref=sr_1_2?ie=UTF8&qid=1325344126&sr=8-2
about 240 pages text, with 740 full text references free online
$ 37.98 paperback -- see:
www.WhileScienceSleeps.com
http://www.amazon.com/review/RNGG3O7U33VCV
Rich Murray,
MA Boston University Graduate School 1967 psychology,
BS MIT 1964 history and physics,
254-A Donax Avenue, Imperial Beach, CA 91932
rmforall@gmail.com
505-819-7388
Skype audio, video rich.murray11
http://RMForAll.blogspot.com
new primary archive
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